The prognostic value of PP2A B56 family members in hepatocellular carcinoma and immune infiltration analysis
Objective To investigate the prognostic value of protein phosphatase 2A(PP2A)B56 family members in hepatocellular carcinoma(HCC).Methods The GEPIA,Kaplan-Meier plotter,cBioPortal,GeneMANIA and TIMER databases were used to analyze the differential expression,prognostic value,genetic alterations,and immune cell infiltration of PP2A B56 family members in HCC patients.Results The expres-sion levels of PPP2R5A,PPP2R5C,PPP2R5D,and PPP2R5E were elevated in HCC tissues.PPP2R5E exhibi-ted a significant correlation with clinical cancer stage and overall survival,and PPP2R5B and PPP2R5D were significantly associated with overall survival or disease-free survival in HCC patients.These findings suggest that PPP2R5D and PPP2R5E may serve as potential prognostic biomarkers for HCC patients.Furthermore,the differentially expressed PP2A B56 family members were functionally involved in glycolysis,protein serine/threonine phosphate complexes,protein dephosphorylation,meiosis,nucleotide metabolism,and the JAK-STAT signaling pathway through interactions with proteins such as SGO1,PFKFB4,PPP2R1A,and NKD1.Additionally,the expression of PP2A B56 members demonstrated a significant correlation with the immune in-filtration of B cells,CD8+T cells,CD4+T cells,macrophages,neutrophils and dendritic cells in HCC.Con-clusion PPP2R5D and PPP2R5E may serve as potential prognostic biomarkers for HCC.
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