Effects of dexmedetomidine on inflammatory factors and outcomes in mechanically ventilated sepsis patients
Objective To investigate the effects of dexmedetomidine(Dex)on inflammatory factors and outcomes in mechanically ventilated sepsis patients.Methods Sixty mechanically ventilated sepsis patients were randomly divided into the dexmedetomidine group(n=31)and the midazolam group(n=29),receiving either dexmedetomidine or midazolam to maintain a RASS score of-2 to 0.Venous blood samples were col-lected before treatment(TO),and at 3 days(T1)and 7 days(T2)post-treatment to measure serum levels of CRP,PCT,and TNF-α.APACHE Ⅱ and SOFA scores were compared between the two groups on the 7th day of sedation.Additionally,the incidence of adverse reactions and the 28-day mortality rate were recorded.Re-sults CRP,PCT,and TNF-α levels significantly decreased in both groups post-treatment,with statistically significant differences compared to pre-treatment levels(P＜0.05).Both APACHE Ⅱ and SOFA scores showed significant improvement post-treatment in both groups(P＜0.05).The declines of CRP,PCT,TNF-α,and APACHE Ⅱ and SOFA scores were significantly greater in the dexmedetomidine group compared to the midazolam group(P＜0.05).There was no statistically significant difference in the incidence of adverse e-vents and the 28-day mortality rate between the two groups(P＞0.05).Conclusion Both dexmedetomidine and midazolam have effective anti-inflammatory effects in mechanically ventilated sepsis patients,with dexme-detomidine showing superior efficacy.
万方数据
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