Diagnostic Value of 18F-FDG PET-CT Combined with Serum SCC-Ag and CYFRA21-1 in the Detection of Retroperitoneal Lymph Node Metastasis in Cervical Squamous Cell Carcinoma
Objective To explore the diagnostic value of 18F-FDG PET-CT combined with serum SCC-Ag and CYFRA21-1 in detecting retroperitoneal lymph node metastasis in cervical squamous cell carcinoma.Methods Based on postoperative pathological examination results,100 female patients with cervical squamous cell carcinoma were divided into the metastasis group(33 cases with retroperitoneal lymph node metastasis)and the non-metastasis group(67 cases without retroperitoneal lymph node metastasis).Preoperative 18F-FDG PET-CT scan data and serum SCC-Ag and CYFRA21-1 levels were collected for each patient.Differences in va-rious indicators between the two groups were compared.Logistic binary multivariate regression analysis was performed to identify independent factors influencing retroperitoneal lymph node metastasis.ROC curve analy-sis was conducted for significant variables.Results The metastasis group had significantly higher levels of serum SCC-Ag,CYFRA21-1,and SUVmax values compared to the non-metastasis group,with statistically significant differences(P＜0.05).Serum SCC-Ag,CYFRA21-1 levels,and SUVmax values were identified as independent factors influencing retroperitoneal lymph node metastasis.ROC curve analysis showed that the AUCs for SCC-Ag,CYFRA21-1,SUVmax alone,and their combination in predicting retroperitoneal lymph node metastasis were 0.769,0.813,0.811,and 0.891,respectively,all of which were statistically significant(P＜0.05).Conclusion The combination of 18 F-FDG PET-CT with serum SCC-Ag and CYFRA21-1 dem-onstrates significant clinical value in diagnosing retroperitoneal lymph node metastasis in cervical squamous cell carcinoma.
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