Correlation between gut microbiota and oral cancer risk:insights from a two-sample Mendelian randomization analysis
Objective To explore the potential causal association between gut microbiota and oral cancer risk using Mendelian randomization(MR)analysis.Methods Summarized data on oral cancer and gut micro-biota were downloaded from the OPEN GW AS database and the MiBioGen consortium,respectively.A two-sample MR analysis was performed,employing the inverse-variance weighted(IVW)method as the primary statistical approach,complemented by MR-Egger,weighted median,weighted mode,and simple mode meth-ods.This analysis aimed to investigate the causal relationship between gut microflora and oral cancer risk.In addition,sensitivity analyses were used to detect heterogeneity and pleiotropy.Results Using the IVW method as the primary statistical approach,the results revealed that Betaproteobacteria(OR=1.001105,P=0.01576412,95％CI:1.0002078～1.002002)、Alcaligenaceae(OR=1.001249,P=0.01154315,95％CI:1.0002797～1.002219)、Pasteurellales(Pasteurellaceae)(OR=1.000510,P=0.03808085,95％CI:1.0000280～1.000993)、Eubacterium fissicatena group(OR=1.000488,P=0.03155466,95％CI:1.0000431～1.000932)and Desulf ovibrio(OR=1.000714,P=0.04466106,95％CI:1.0000170～1.001412)were associ-ated with an increased risk of oral cancer,suggesting a potential promoting effect.In contrast,Butyrivibrio(OR=0.9996003,P=0.02473086,95％CI:0.9992516～0.9999492)and Clostridium sensu stricto 1(OR=0.9986777,P=0.001871154,95％CI:0.9978452--0.9995109)had an inhibitory effect on oral cancer devel-opment.Conclusion The MR analysis evaluating the causal relationship between gut microbiota and oral cancer reveals that five bacterial genera(including Pasteurellaceae and Pasteurellales,which belong to the same genus)are associated with an increased risk of oral cancer,while two genera exhibit a protective effect.
oral cancergut microbiotaoral cancer riskMendelian randomization
万方数据
维普
