NT5DC2 as a potential tumor marker for triple-negative breast cancer
Objective This study employed bioinformatics to investigate the role of NT5DC2 gene in tri-ple-negative breast cancer(TNBC)and to explore its potential as a tumor marker.Methods mRNA expres-sion data and corresponding clinical data of patients with breast cancer were obtained from the TCGA database;the single-cell sequencing data of TNBC patients were obtained from the GEO database.R language was uti-lized to analyze NT5DC2 expression,machine learning,survival,immune infiltration,GSEA gene enrichment,and single-cell sequencing data.Results The expression level of NT5DC2 in triple-negative breast cancer tis-sues was significantly upregulated compared to normal tissues and non-TNBC tissues.High NT5DC2 expres-sion was associated with poorer overall survival in TNBC patients.The NT5DC2 gene had high diagnostic value in TNBC patients.The expression level of NT5DC2 was negatively correlated with the infiltration of multiple immune cells,and various immune-related functions and pathways.In addition,high NT5DC2 expression indi-cated a higher tumor purity in TNBC.Finally,NT5DC2 was significantly overexpressed in TNBC epithelial cells,but almost not expressed in immune cells,suggesting that NT5DC2 may promote the progression of TN-BC by suppressing immune cells.Conclusion The NT5DC2 gene may serve as a diagnostic and prognostic bi-omarker for TNBC,and may promote the progression of TNBC by inhibiting immune cells.
NT5DC2 genetriple-negative breast cancerbioinformatics
NETL
NSTL
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