The mediating role of sarcopenia and Frailty in nutrition and quality of life in patients with chronic kidney disease
Objective To investigate the mediating role of sarcopenia and frailty between nutrition and quality of life in patients with chronic kidney disease(CKD),providing a reference for formulating targeted in-tervention measures to improve patients'quality of life.Methods 605 patients with CKD were selected using convenience sampling method.Data were collected using a general information questionnaire,the SARC-F questionnaire,the Frail Frailty scale and MNA-SF Mini-nutrition Rating Scale.Results The study found that nutritional scores were negatively correlated with scores of frailty and sarcopenia(r=-0.581,r=-0.561,P＜0.001),while sarcopenia scores were positively correlated with frailty scores(r=0.760,P＜0.001).Further regression analysis highlighted the mediating effect of sarcopenia between nutrition and frail-ty.Equation 1 showed that nutritional scores negatively predicted frailty scores(β=-0.435,P＜0.001),ex-plaining 31.9％of the variance.Equation 2 revealed that nutritional scores negatively predicted sarcopenia scores(β=-0.763,P＜0.001),accounting for 30.8％of the variance.In equation 3,nutritional scores(β=-0.157,P＜0.001)and sarcopenia scores(β=0.365,P＜0.001)significantly predicted frailty scores,to-gether explaining 61.2％of the variance.The Bootstrap method confirmed the significant total,direct,and in-direct effects in the nutrition-frailty pathwaywith sarcopenia's mediating effect accounting for 64.0％of the to-tal effect.Conclusion Sarcopenia and frailty play significant mediating roles between nutrition and quality of life in CKD patients.Healthcare providers should implement personalized interventions based on patients'clin-ical characteristics,emphasizing nutritional support and physical strength enhancement to improve patients'quality of life.
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