Risk factors and nomogram model for adverse NRDS outcomes in preterm infants
Objective To identify the risk factors for adverse outcomes of neonatal respiratory distress syndrome(NRDS)in preterm infants and construct a nomogram model.The findings will provide a theoretical basis for reducing adverse NRDS outcomes in this vulnerable population.Methods 453 preterm infants with NRDS were analyzed and divided into poor and good outcome groups.Univariate analysis and multivariate lo-gistic regression were used to establish a nomogram model.Results Univariate analysis revealed statistically significant differences(P＜0.05)in several factors,including preterm birth category,birth weight,gestation-al age-weight relationship,pulmonary hypertension,necrotizing enterocolitis(NEC)/digestive tract hemor-rhage,sepsis,pulmonary hemorrhage,lactate dehydrogenase levels,pH,cesarean section,cicatricial uterus,ventilation mode,pulmonary surfactant(PS)usage,duration of non-invasive and invasive ventilation,and al-bumin use.Multivariate logistic regression analysis identified the following influential factors for adverse out-comes:preterm birth category,gestational age-weight relationship,pulmonary hypertension,NEC/digestive tract hemorrhage,pulmonary hemorrhage,lactate dehydrogenase levels,and duration of non-invasive ventila-tion.Based on these factors,we developed a nomogram model for risk prediction of adverse outcomes.Receiv-er operating characteristic(ROC)curve and calibration curves were used to evaluate predictive value and effica-cy of the nomogram model.Conclusion Several factors contribute to poor NRDS prognosis in preterm in-fants.These include very preterm/early preterm birth,small-for-gestational-age infants,pulmonary hyperten-sion,NEC/digestive tract hemorrhage,pulmonary hemorrhage,and elevated lactate dehydrogenase levels.The risk of adverse NRDS outcomes in preterm infants can be predicted according to the risk column diagram,enabling early intervention to reduce the incidence of adverse outcomes.
preterm infantsneonatal respiratory distress syndrome(NRDS)adverse outcomesrisk factorsnomogram model
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