血PLR、NLR和LA值在早期评估急性敌草快中毒患者预后的临床价值
The clinical value of serum PLR,NLR and LA values in early prognosis assessment of patients with acute diquat poisoning
沈玉兰 1黄昌保 1薛祥1
作者信息
- 1. 皖南医学院第一附属医院急诊科,安徽 芜湖 241000
- 折叠
摘要
目的 探讨血清血小板淋巴细胞比率(PLR)、中性粒细胞淋巴细胞比率(NLR)、乳酸(LA)值在早期评估急性敌草快中毒患者预后的临床价值.方法 回顾性分析从2020年1月至2023年1月,皖南医学院第一附属医院急诊科收治的87例急性口服农药敌草快(DQ)中毒的患者.根据患者服药后28 d的生存情况,将患者分为DQ生存者(n=45)和DQ死亡组(n=42),比较各组病人的临床资料.采用单因素、多因素Logistic回归分析和绘制受试者工作特征(ROC)曲线判断PLR、NLR以及LA值在早期评估急性DQ中毒患者预后的临床价值.结果 单因素分析提示:DQ死亡组血尿素氮(BUN)、肌酐(Cr)、PLR、NLR、LA值高于DQ存活组,差异有统计学意义(P＜0.05);多因素Logistic回归分析显示:血 PLR(OR=1.022,95％CI:1.004～1.040,P=0.015)、NLR(OR=1.096,95％CI:1.016～1.183,P=0.018)及LA(OR=1.723,95％CI:1.122～2.647,P=0.013)升高是DQ中毒死亡预后发生的危险因素;血清PLR、NLR、LA以及三者联合的ROC曲线下面积(AUC)分别为0.799、0.698、0.760、0.839.结论 患者血清PLR、NLR和LA可作为早期评估DQ中毒患者预后的可靠指标,三项联合早期诊断价值高于各自单独预测.
Abstract
Objective To evaluate the clinical value of serum platelet-lymphocyte ratio(PLR),neutro-phil-lymphocyte ratio(NLR)and lactic acid(LA)in the early prognosis assessment of patients with acute diquat poisoning.Methods A retrospective study was conduced on 87 patients with acute diquat(DQ)poi-soning admitted to the Emergency Department of The First Affiliated Hospital of Wannan Medical College from January 2020 to January 2023.Patients were divided into DQ survival(n=45)and DQ death(n=42)groups,and the based on their 28-day survival outcomes.We compared clinical data between groups and used univariate and multivariate logistic regression analyses along with receiver operating characteristic(ROC)curves to determine the clinical value of PLR,NLR and LA in early prognosis assessment.Results Univari-ate logistic regression analysis revealed significantly higher levels of blood urea nitrogen(BUN),creatinine(Cr),PLR,NLR and LA in DQ death group compared to the survival group(P＜0.05).Multivariate logistic regression analysis showed PLR(OR=1.022,95％CI:1.004～1.040,P=0.015),NLR(OR=1.096,95％CI:1.016～1.183,P=0.018)and LA(OR=1.723,95％CI:1.122～2.647,P=0.013)elevationas risk factors for mortality in diquat poisoning.The areas under the ROC curve(AUC)for serum PLR,NLR,LA,and their combination were 0.799,0.698,0.760 and 0.839,respectively.Conclusion Serum PLR,NLR and LA may serve as reliable indicators for early prognosis assessment in patients with diquat poisoning.The combined use of these three markers provides superior diagnostic value compared to individual predictors,of-fering a valuable tool for early risk stratification and management of acute diquat poisoning cases.
关键词
敌草快中毒/血小板淋巴细胞比率/中性粒细胞淋巴细胞比率/乳酸Key words
diquat poisoning/platelet-lymphocyte ratio/neutrophil-lymphocyte ratio/lactic acid引用本文复制引用
基金项目
中国博士后科学基金项目(2020M670089ZX)
出版年
2024
NETL
NSTL
万方数据