The clinical value of serum PLR,NLR and LA values in early prognosis assessment of patients with acute diquat poisoning
Objective To evaluate the clinical value of serum platelet-lymphocyte ratio(PLR),neutro-phil-lymphocyte ratio(NLR)and lactic acid(LA)in the early prognosis assessment of patients with acute diquat poisoning.Methods A retrospective study was conduced on 87 patients with acute diquat(DQ)poi-soning admitted to the Emergency Department of The First Affiliated Hospital of Wannan Medical College from January 2020 to January 2023.Patients were divided into DQ survival(n=45)and DQ death(n=42)groups,and the based on their 28-day survival outcomes.We compared clinical data between groups and used univariate and multivariate logistic regression analyses along with receiver operating characteristic(ROC)curves to determine the clinical value of PLR,NLR and LA in early prognosis assessment.Results Univari-ate logistic regression analysis revealed significantly higher levels of blood urea nitrogen(BUN),creatinine(Cr),PLR,NLR and LA in DQ death group compared to the survival group(P＜0.05).Multivariate logistic regression analysis showed PLR(OR=1.022,95％CI:1.004～1.040,P=0.015),NLR(OR=1.096,95％CI:1.016～1.183,P=0.018)and LA(OR=1.723,95％CI:1.122～2.647,P=0.013)elevationas risk factors for mortality in diquat poisoning.The areas under the ROC curve(AUC)for serum PLR,NLR,LA,and their combination were 0.799,0.698,0.760 and 0.839,respectively.Conclusion Serum PLR,NLR and LA may serve as reliable indicators for early prognosis assessment in patients with diquat poisoning.The combined use of these three markers provides superior diagnostic value compared to individual predictors,of-fering a valuable tool for early risk stratification and management of acute diquat poisoning cases.
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