Study on the expression and clinical correlation of serum MMP-2 and MMP-9 in patients with lupus nephritis
Objective To investigate the expression of matrix metalloproteinases(MMP-2 and MMP-9)in the serum of patients with lupus nephritis(LN)secondary to systemic lupus erythematosus(SLE)and its cor-relation with disease activity,and to analyze the potential correlation between changes in peripheral blood lym-phocyte subsets in patients with active SLE LN and the progression of LN.Methods ①Fifty-one patients with SLE LN admitted between June 2021 and June 2023 were enrolled and divided into an active group(SLE-DAI≥10)and an inactive group(SLEDAI＜10)based on the Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)score,and 45 healthy individuals serving as a control group.②Serum levels of MMP-2 and MMP-9 were collected and measured in all three groups.③Expression levels of ANA,anti-dsDNA,hs-CRP,IgA,IgG,IgM,and complement C3 and C4 were measured in active SLE LN patients.④Correlations between MMP-2,MMP-9,and the aforementioned disease activity markers were analyzed.⑤Peripheral blood lympho-cyte subsets were assessed using flow cytometry in active SLE LN patients.Results ①Serum MMP-2 levels were significantly higher in the active SLE LN group compared to the inactive group and the control group(P＜0.05),while MMP-9 levels were significantly lower(P＜0.05).②In the active SLE LN group,serum MMP-2 was positively correlated with ANA,dsDNA,hs-CRP,and IgG,and negatively correlated with com-plement C3 and C4;MMP-9 was negatively correlated with ANA,dsDNA,and IgG,and positively correlated with complement C4(P＜0.05).③MMP-9 was positively correlated with the percentage of T cells(P＜0.05).Conclusion The expression of MMP-2 and MMP-9 in the serum of active SLE LN patients is closely associated with disease activity and may serve as biomarkers for early diagnosis and assessment of disease activ-ity.
万方数据
维普
