Core acupoints and their potential targets of acupuncture therapy for gouty arthritis based on data mining
曹洋 1储易凡 1李庚 2朱艳3
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作者信息
1. 安徽中医药大学研究生院,安徽 合肥 230012
2. 云南中医药大学第二临床医学院,云南 昆明 650500
3. 安徽中医药大学第二附属医院,安徽 合肥 230022
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摘要
目的 利用数据挖掘的方法探析针灸治疗痛风的核心处方及其靶点,为临床选穴和基础研究提供参考.方法 以中国知网、万方数据库、中国生物医学文献数据库、维普期刊数据库及PubMed、Web of Science中的文献为数据源,应用R语言对针灸治疗痛风的处方进行关联规则和聚类分析发现核心穴方,并进一步对核心穴方进行潜在靶点挖掘.结果 针灸治疗痛风的核心穴方为足三里、三阴交、阴陵泉、阿是穴,其潜在靶点17个.结论 针灸干预痛风的主穴可以多靶点、多通路协同实现治疗效果.
Abstract
Objective To explore the core prescriptions and their targets of acupuncture therapy for gout using data mining methods and to provide references for clinical acupoint selection and basic research.Meth-ods The literature sourced for this study comes from China National Knowledge Infrastructure,Wanfang Da-ta,China Biology Medicine database,China Science and Technology Journal Database,PubMed,and Web of Science.The R language was used to discover core acupoint prescriptions by association rules and cluster analy-sis of prescriptions for acupuncture treatment of gout,and further explore the potential targets of the core acu-point prescriptions.Results The core acupoint prescriptions for the treatment of gout by acupuncture were Zusanli,Sanyinjiao,Yinlingquan and Ashi points,with 17 potential targets identified.Conclusion The main acupoints used in acupuncture intervention for gout can achieve therapeutic effects through the synergistic ac-tion of multiple targets and pathways.
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