Meta-analysis of the clinical efficacy of Guasha in the treatment of knee osteoarthritis
王冬红 1李昊阳 1凡丹 1侯婷婷 1田佳欢 1周薇1
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作者信息
1. 广西中医药大学护理学院,广西 南宁 530001
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摘要
目的 评价刮痧治疗膝骨关节炎的临床疗效及其安全性,为临床决策提供更多的循证依据.方法 计算机检索维普(VIP)、万方(WanFang)、中国知网(CNKI)、CBM、PubMed、Web of Science、Embase等7大数据库中有关刮痧治疗膝骨性关节炎的随机对照试验,检索时间为建库至2024年1月10日,筛选出与纳入和排除标准一致的文献,应用Re-view Manager 5.4软件对数据进行分析.结果 本文最后共纳入13篇文献,共855例,其中对照组429例,治疗组426例,结果显示刮痧在提高总体有效率[OR=6.34,95％CI(3.53,11.36)]、Lysholm 评分[MD=6.43,95％CI(3.28,9.59)]、降低 VAS 评分[MD=-1.09,95％CI(-1.35,0.83)]、膝围积分[MD=-2.00,95％CI(-2.94,-1.06)]、TNF-α浓度[SMD=-1.16,95％CI(-1.52,-0.81)]等方面具有统计学意义,安全性方面治疗组与对照组之间的差异无统计学意义(P＞0.05).结论 刮痧治疗膝骨性关节炎,在提高总体有效率、Lysholm评分以及降低VAS评分、TNF-α浓度方面更有优势,可有效改善患者生存质量.
Abstract
Objective To evaluate the clinical efficacy and safety of Guasha in the treatment of knee osteo-arthritis and to provide more evidence-based basis for clinical decision-making.Methods Randomized con-trolled trials on Guasha in the treatment of knee osteoarthritis were retrieved by computer from seven major da-tabases including VIP,WanFang,CNKI,CBM,PubMed,Web of Science and Embase.The search period cov-ered from the inception of the databases to January 10,2024.Relevant papers that met the inclusion and exclu-sion criteria were screened and analyzed using Review Manager 5.4 software.Results A total of 13 papers involving 855 patients were included in this meta-analysis,with 429 patients in the control group and 426 pa-tients in the treatment group.The results showed that Guasha had statistically significant effects in improving the overall effective rate[OR=6.34,95％CI(3.53,11.36)],Lysholm score[MD=6.43,95％CI(3.28,9.59)],reducing VAS score[MD=-1.09,95％CI(-1.35,-0.83)],knee circumference score[MD=-2.00,95％CI(-2.94,-1.06)]and TNF-α concentration[SMD=-1.16,95％CI(-1.52,-0.81)].There was no statistically significant difference in safety between the treatment group and the control group(P＞0.05).Conclusion Guasha in the treatment of knee osteoarthritis has more advantages in improving the o-verall effective rate,Lysholm score,reducing VAS score,and TNF-α concentration,which can effectively im-prove patients'quality of life.
维普
万方数据