Combination therapy of Tongfengkang and external application of traditional Chinese medicine for gouty arthritis with damp-heat accumulation type
Objective To investigate the therapeutic effect of Tongfengkang combined with external appli-cation of traditional Chinese medicine(TCM)in patients with gouty arthritis of damp-heat accumulation type.Methods A total of 80 patients with gouty arthritis of damp-heat accumulation type who visited Suzhou Hospital of Traditional Chinese Medicine from January 2023 to January 2024 were selected and divided into a study group(n=40,treated with Tongfengkang combined with external application of TCM)and a control group(n=40,treated with celecoxib)using a double-blind method.After 14 days of treatment,the scores of joint redness and swelling,joint pain,joint dysfunction,the levels of serum creatinine(Scr),blood uric acid(BUA),white blood cells(WBC),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),overall clinical ef-fectiveness,and incidence of adverse drug reactions were observed and compared between the two groups to e-valuate the treatment outcomes.Results ①Compared with pre-treatment levels,both the study group and the control group showed reductions in joint redness and swelling scores,joint pain scores,joint dysfunction scores,Scr,BUA,WBC,IL-6 and TNF-α levels after treatment,with statistically significant differences(P＜0.05).②Compared between the study group and the control group,statistically significant differences were observed in joint redness and swelling scores,joint pain scores,joint dysfunction scores,Scr,BUA,WBC,IL-6 and TNF-α levels(P＜0.05).③The overall effectiveness rate of the study group(97.50％)was significant-ly different from that of the control group(82.50％),and the difference was statistically significant(P＜0.001).④The incidence of adverse reactions in the study group(5.00％)was significantly lower than that in the control group(30.00％)after treatment,with a statistically significant difference(P＜0.05).Conclu-sion The combination therapy of Tongfengkang and external application of TCM in the treatment of gouty ar-thritis with damp-heat accumulation type has certain clinical efficacy and higher medication safety.
gouty arthritisTongfengkangexternal application of traditional Chinese medicineCelecox-ib
万方数据
维普
