In the paper,zinc oxide dust and mechanically activated dust were used as raw materials to study the effects of sulfuric acid concentration,liquid-solid ratio,leaching time,leaching tempera-ture and stirring speed on the leaching effect of the two experimental raw materials,and the optimal pa-rameters were as follows:sulfuric acid concentration of 100 g/L,liquid-solid ratio of 5 mL/g,leac-hing time of 90 min,leaching temperature of 60 ℃,and stirring speed of 500 r/min.Under these conditions,the zinc leaching rate of mechanically activated dust is increased by 10 percentage points compared with that of primary zinc oxide dust,which can reach more than 85%.The leaching rate of iron in both materials is maintained at about5%~10%,and indium and lead are almost not leached.