Objective To observe the efficacy and safety of penetrating canaloplasty without viscoelastic for primary open angle glaucoma(POAG).Design Prospective case series.Participants 25 patients(35 eyes)with POAG penetrating canaloplasty without vis-coelastic at Cangzhou Aier Eye Hospital from December 2021 to June 2022 were treated.Methods Record preoperative and postopera-tive intraocular pressure(IOP),number of anti-glaucoma drugs,LogMAR best corrected visual acuity(BCVA),average retinal nerve fiber layer(RNFL)thickness,vertical C/D,average gangline cell layer(GCL)thickness in the macular area,intraoperative and postoperative complications.Time points of follow-up were arranged at 1 day,7 days,1 month,3 months,6 months,and 1 year after the surgery.Complete success was defined as IOP ≤21 mmHg without any glaucoma medications.Qualified success was defined as IOP≤21 mmHg with glaucoma medications(within 2 types).Main Outcom Measures Rate of circumferential catheterization of the canal,IOP,surgical success rate,and intraoperative and postoperative complications.Results 33 eyes(94.3％)achieved the 360 degrees'catheterization of the canal without viscoelastic.All patients completed a 12 month follow-up,with an average preoperative IOP of(25.8±7.7)mmHg.The postoperative IOP at 1 day,7 days,1 month,3 months,6 months,and 1 year were(14.1±6.1),(13.3±4.9),(14.8±4.4),(15.0±4.8),(15.2±4.0)and(14.7±3.6)mmHg,respectively.There were statistically significant differences between the preoperative and postoper-ative IOP(all P＜0.001).The complete success rate and qualified success rate at 1 year after surgery were 90.9％(30/33)and 97.0％(32/33),respectively.Conclusion The penetrating canaloplasty without viscoelastic is safe and effective for the treatment of POAG.Which has a significant short-term effect on reducing IOP.(Ophthalmol CHN,2023,32:16-20)
expansion without viscoelasticpenetrating canaloplastyprimary open-angle glaucoma
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