Objective Using optical coherence tomography angiography(OCTA)to observe the changes in macular blood flow density and macular thickness in patients with femtosecond laser cataract surgery.Design Retrospective comparative case series.Par-ticipants From July 2020 to June 2021,60 patients(60 eyes)diagnosed wwith age-related cataract and treated with surgery in Shenzhen Aier Eye Hospital were selected.30 patients(30 eyes)who underwent femtosecond laser-assisted cataract surgery(femtosecond laser group)and 30 patients(30 eyes)who underwent common phacoemulsification cataract surgery(traditional phacoemulsification group).Methods Patients in each group underwent OCTA examination before surgery,1 day,1 week,1 month,and 3 months after surgery.The superficial retinal blood flow perfusion density in the macular area 3 mm×3 mm(3 mm)and 6 mm×6 mm(6 mm)and the 3 mm macular area of all patients were recorded.Intra-layer and full-layer retinal thickness were measured and compared.Main Outcome Measures Blood flow density and macular thickness.Results Superficial retinal blood flow density in the macular region of 3 mm and 6 mm:fem-tosecond laser group decreased in 1 day,1 week and 1 month after surgery compared with that before surgery(P(3mm)=0.016,0.014,0.011,P(6 mm)=0.042,0.013,0.007).In traditional phacoemulsification group,the blood flow density decreased in 1 day and 1 week after opera-tion(P(3mm)=0.033,0.040,P(6mm)=0.031,0.040).The superficial retinal blood flow density in the 3 mm and 6 mm areas in traditional pha-coemulsification group was significantly higher than that in the femtosecond laser group at 1 month after surgery(t=3.536,P=0.001;t=3.259,P=0.003).Retinal thickness of 3 mm in macular area:the average thickness of inner and whole retinal in traditional phacoemul-sification group increased at 1 month and 3 months after surgery compared with the preoperative thickness(P=0.036,0.031;P=0.019,0.016),and showed an increasing trend with time,and tended to be stable at 3 months after surgery.The average thickness of inner retina and whole retina in femtosecond group increased at 1 week,1 month and 3 months after operation(P=0.045,0.020,0.005;P=0.038,0.027,0.007),and showed an increasing trend with time,and tended to be stable at 3 months after surgery.There was no signifi-cant difference in the average thickness of inner and whole retina between the two groups at each time(all P＞0.05).Conclusion The superficial retinal blood flow density and retinal thickness in the macular area of femtosecond laser-assisted cataract surgery patients showed no difference 3 months after surgery compared with traditional phacoemulsification cataract surgery patients.Femtosecond laser-assisted cataract surgery is a safer surgical method.(Ophthalmol CHN,2024,33:99-104)
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