Objective To analyze the clinical characteristics associated with dry eye disease(DED)in China.Design Multicenter clinical research.Participants A total of 4497 patients with a diagnosis of DED from 8 Aier Eye Hospitals(Shenyang,Beijing,Harbin,Chongqing,Changsha,Chengdu,Wuhan and Guangzhou)in China.Methods The clinical data of patients with DED from June 2017 to June 2019 were collected.The Ocular Surface Disease Index(OSDI),the Chinese Dry Eye Questionnaire was administered,and ocular surface staining,Schirmer's test,and fluorescein breakup time test(FBUT)were performed,and meibomian scores were calculated.The patients were classified into North group(Beijing,Shenyang,Harbin)and South group(Chongqing,Wuhan,Changsha,Chengdu,Guangzhou).The types of DED were purely aqueous deficient,purely evaporative and mixed-type groups.The severity of DED was grad-ed into mild,moderate and severe.Main Outcome Measures OSDI,China Dry Eye Questionnaire,FBUT,Schirmer's test,corneal flu-orescent staining and meibomian gland score.Results A total of 4497 patients were included in the study.127 cases(3.0％)were clas-sified as having purely aqueous-deficient dry eye,2308 cases(53.7％)were classified as having purely evaporative dry eye resulting from meibomian gland dysfunction(MGD),and 1864 cases(43.4％)were classified as having mixed-type dry eye.Overall,92.8％of these patients showed signs of MGD.Among the patients,3970 cases(88.3％)were mild,381 cases(8.5％)were moderate and 119 cas-es(2.6％)were severe.The Schirmer test in North group(8.1±6.6 mm)was lower than that in South group(9.6±7.4)mm(t=-6.470,P＜0.001).OSDI in North group(22.3±14.4)was higher than that in South group(20.7±13.2)(t=3.652,P＜0.001),and meibomian scores in North group(1.6±0.7)was higher than that in South group(1.5±0.7)(t=5.351,P＜0.001).The proportions of moderate(9.9％)and se-vere(3.5％)DED were higher in North group than that in South group(5.4％,0.9％).Conclusion The proportion of dry eye patients as-sociated with MGD is very high in many dry eye clinics in China.The proportions of moderate and severe DED were higher in North group than in South group in China.(Ophthalmol CHN,2024,33:120-125)
dry eye diseasemeibomian gland dysfunctionmulticenter study
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