Objective To investigate the efficiency of 532nm micropulse laser trabeculoplasty(MLT)in reducing intraocular pres-sure(IOP)in patients with primary open-angle glaucoma(POAG).Design Retrospective case-series.Participants 43 patients with POAG.Methods 22 patients received MLT as the initial treatment,while 21 patients received topical medication as the initial treatment but failed to achieve the target IOP or showed progressive narrowing of visual field or thinning of the nerve fiber layer,and then MLT was used as additional treatment.All cases were treated with unified laser parameters and operated by the same ophthalmologist.Main Outcome Measures IOP reduction,treatment success rate.Results 1OP after laser treatment 1 hour,1 day,1 week,1 month,3 month,and 6 month were(19.9±4.7)mmHg,(17.9±4.5)mmHg,(18.5±4.4)mmHg,(16.8±4.2)mmHg,(16.7±4.2)mmHg and(17.5±5.2)mmHg,respectively(F=3.088,P=0.006).Both the MLT group and the drug combined MLT group reached the maximum IOP reduction at 1 month after laser surgery.Compared with the group with normal baseline IOP,the amplitude of postoperative IOP reduction was larger in patients with elevated IOP after 1 day,1 week,1 month,3 month,and 6 month treatment(all P＜0.001).The IOP decreased by about 17.8％from baseline at 1 month follow-up.The overall success rate was 50.0％at 6 months follow-up,54.2％in the drug combined MLT group and 42.9％in the MLT group(x2=1.42,P=0.39).Hyphema,cornea injuries were not observed in all treated patients.Con-clusion 532 nm MLT is effective and safe to be used as an initial treatment in patients with POAG,also a good assistant treatment for patients with topical medication.(Ophthalmol CHN,2024,33:182-186)
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