Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare yet severe drug-induced mucocutaneous conditions,frequently presenting with acute and chronic ocular complications.Severe cases can result in blindness.The incidence of oc-ular involvement is high in patients during the acute phase,yet ocular conditions are often overlooked.Early diagnosis and aggressive anti-inflammatory treatment,including amniotic membrane transplantation,are crucial to mitigate damage and prevent severe late-stage complications,and enhance the quality of life for patients.This paper emphasizes the importance of early ophthalmic management in SJS-TEN,aiming to raise awareness of ocular complications,promote early diagnosis and intervention,reduce vision loss risk,and im-prove the long-term quality of life for patients.(Ophthalmol CHN,2024,33:245-248)