Stevens-Johnson综合征及中毒性表皮坏死松解症的早期眼部诊疗管理
The early ophthalmic diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis
何彦 1刘颖怡1
作者信息
- 1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室 100730
- 折叠
摘要
Stevens-Johnson 综合征(Stevens-Johnson syndrome,SJS)和中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)是由药物引发的罕见但极为严重的皮肤黏膜疾病,常伴随眼部的急慢性并发症,甚至导致失明,严重影响患者的生活质量.急性期患者的眼部受累率很高,但对眼部状况的重视程度尚不够.早期诊断和积极强化的抗炎治疗甚至羊膜移植,对减缓损伤进展、防止晚期严重并发症的发生、改善患者生活质量至关重要.本文强调了 SJS-TEN早期眼部诊疗的重要性,旨在提高对其眼部并发症的认识,促进更加积极明确的早期诊断和治疗,以降低视力损伤风险,提升患者远期生活质量.(眼科,2024,33:245-248)
Abstract
Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare yet severe drug-induced mucocutaneous conditions,frequently presenting with acute and chronic ocular complications.Severe cases can result in blindness.The incidence of oc-ular involvement is high in patients during the acute phase,yet ocular conditions are often overlooked.Early diagnosis and aggressive anti-inflammatory treatment,including amniotic membrane transplantation,are crucial to mitigate damage and prevent severe late-stage complications,and enhance the quality of life for patients.This paper emphasizes the importance of early ophthalmic management in SJS-TEN,aiming to raise awareness of ocular complications,promote early diagnosis and intervention,reduce vision loss risk,and im-prove the long-term quality of life for patients.(Ophthalmol CHN,2024,33:245-248)
关键词
Stevens-Johnson综合征/中毒性表皮坏死松解症/干眼/眼表损伤Key words
Stevens-Johnson syndrome/toxic epidermal necrolysis/dry eye/ocular surface injury引用本文复制引用
基金项目
北京市医师科学家培养计划(BJPSTP-2024-06)
出版年
2024
NETL
NSTL
万方数据