Objective To explore the mechanism for immediate IOP effects that occur from a single dose of latanoprost.Design One-factor repeated-measures design.Participants 15 eyes with primary open angle glaucoma were treated naively with latanoprost.Methods Intraocular pressure(IOP)and video imaging of aqueous vein were captured before and 10-min,30-min,45-min,60-min,120-min and 240-min after instillation of latanoprost.Main Outcome Measures IOP,aqueous stratum diameter(ASD)and aqueous ve-locity(AV).Results Before medication instillation,IOP was(28.3±4.2)mmHg.It started to dramatically decrease to(24.3±2.3)mmHg after 120 minutes(F=10.203,P=0.006).Before medication instillation,ASD was(0.019±0.010)μm.It started to dramatically increase to(0.034±0.007)μm after 45 minutes(F=26.187,P＜0.001),which kept increasing to(0.050±0.012)μm until 60 minutes afterwards(F=20.723,P＜0.001).Before medication instillation,AV was(2.1±0.5)μl/s.It started to dramatically increase to(2.6±0.6)μl/s after 30 minutes(F=5.757,P=0.031),which kept increasing to 4.3±0.9 μl/s at 45-minute and(4.3±0.9)μl/s at 60 minutes as well(F30-45=8.512,P30-45=0.0 11;F45-60=6.719,P45-60=0.021).Conclusion Latanoprost increase aqueous through trabecular meshwork pathway resulting imme-diate IOP drop.(Ophthalmol CHN,2024,33:257-260)
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