The preliminary efficacy of raising blood pressure for normal tension glaucoma with hypotension
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维普
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目的 探讨生脉饮对伴有低血压的正常眼压性青光眼(NTG)患者的临床效果.设计非随机对照临床试验.研究对象将伴有低血压NTG患者30例分为两组,其中研究组17例(33眼),对照组13例(26眼).方法 研究组采用降眼压滴眼剂治疗并口服生脉饮(10 ml,日3次),对照组仅采用降眼压滴眼剂治疗,连续治疗6个月后在第3个月和第6个月评价眼压、视野、血压等.视野指数(VF1)提升或下降≥3％为视野好转或下降.主要指标眼压、收缩压(SBP)、舒张压(DBP)、眼灌注压(OPP)、视野指数(VFI).结果 研究组和对照组入选时平均眼压分别为(13.94±2.23)mmHg和(16.80±2.65)mmHg,治疗3、6个月后,研究组眼压分别较治疗前升高(0.17±0.06)mmHg(P=0.744)、(0.22±0.03)mmHg(P=0.468),对照组较治疗前分别降低(0.88±0.25)mmHg(P=0.177)和(1.94±0.81)mmHg(P=0.003).研究组 SBP、DBP 和 OPP 值均较治疗前升高(P=0.012、0.006、＜0.001、＜0.001、＜0.001、＜0.001),与同期对照组相比均有显著性差异(P=0.049、0.045、＜0.001、＜0.001、0.018、0.033).治疗6个月后,研究组中21.21％(7眼)VFI提高≥3％,78.79％(26眼)没有变化,0眼VFI下降≥3％,而对照组0眼VFI提高≥3％,96.15％(25眼)没有变化,3.85％(1眼)VFI下降≥3％.治疗6个月与治疗前相比VFI有显著性差异(P=0.012).结论 生脉饮能够提高伴有低血压的NTG患者的动脉血压和眼灌注压,同时可伴有视野指数的改善.(眼科,2024,33:345-349)
Objective To observe the clinical effect of Shengmaiyin on normal tension glaucoma(NTG)patients with hypotension.Design Non-randomized controlled trial.Participants Thirty patients with NTG with hypotension were divided into two groups,includ-ing 17 patients(33 eyes)in the study group and 13 patients(26 eyes)in the control group.Method The study group was treated with reducing intraocular pressure(IOP)eye drops and oral Shengmaiyin(10 ml,tid),while the control group was treated with reducing IOP eye drops only.IOP,blood pressure and visual field were evaluated at the third and sixth months after continuous treatment for 6 months.Visual field index(VFI)improvement or decline of ≥3％was defined as visual field improvement or decline.Main Outcome Measures IOP,systolic blood pressure(SBP),diastolic blood pressure(DBP),ocular perfusion pressure(OPP)and visual field index(VFI).Results The average IOP of the study group and the control group was(13.94±2.23)mmHg and(16.80±2.65)mmHg,respective-ly.After 3 months and 6 months of treatment,the IOP of the study group was increased by(0.17±0.06)mmHg(P=0.744)and 0.22±0.03 mmHg(P=0.468),respectively.The control group decreased by(0.88±0.25)mmHg(P=0.177)and(1.94±0.81)mmHg(P=0.003),respec-tively.The values of SBP,DBP and OPP in the study group were higher than those before treatment(P=0.012,0.006,＜0.001,＜0.001,＜0.001,＜0.001).There were significant differences compared with the control group(P=0.049,0.045,＜0.001,＜0.001,0.018,0.033).After 6 months of treatment,the VFI of 21.21％(7 eyes)in the study group increased by ≥ 3％,78.79％(26 eyes)showed no change,and the VFI of 0 eyes decreased by ≥3％,while that of 0 eyes in the control group increased by ≥ 3％,96.15％(25 eyes)showed no change,and 3.85％(1 eye)visual field VFI decreased by ≥3％.After 6 months of treatment,VFI was significantly different from that before treat-ment(P=0.012).Conclusion Shengmaiyin can increase arterial blood pressure and ocular perfusion pressure in NTG patients with hy-potension,as well as improve visual field index.(Ophthalmol CHN,2024,33:345-349)
normal tension glaucomaShengmaiyinvisual field index
维普
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