Long-term effect of orthokeratology on choroidal thickness and choroidal contour in myopic children
Objective:To investigate the long-term effect of orthokeratology on the choroidal thickness and choroidal contour in myopic children.Methods:Subjects were from a conducted 2-year Randomized Clinical Trial.Children(n=80)aged 8-12 years with spherical equivalent refraction of-1.00 to-6.00 D were randomly assigned to the control group(n=40)and ortho-k group(n=40).OCT images were collected at the baseline,1-,6-,12-,18-,and 24-month visits,then the choroidal thickness and choroid contour were calculated.Axial length(AL)and other ocular biometrics were also measured.Results:During two years,in the control group,the choroidal thickness became thinning and the choroidal contour became prolate with time at all visits(all P<0.001).Ortho-k can improve the choroidal thickness(all P<0.001)and maintain the choroidal contour at all visits(all P<0.05).In the ortho-k group,the choroidal contour was less changed in the temporal than nasal(P=0.008),and the choroidal thickness was more thickening in the temporal 3 mm(P<0.001).Two-year change in choroidal thickness was significantly associated with the two-year AL change in the control group(r=-0.52,P<0.001),however,this trend was broken by ortho-k(r=-0.05,P=0.342).After being adjusted by other variables in the multivariable regression model,the effect of ortho-k on choroidal thickness was stable.Conclusions:In a short term,ortho-k can improve the choroidal thickness and maintain the choroidal contour,but this effect diminished in a long term.Further study with larger sample size and longer follow-up is warranted to refine this issue.
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维普
