Influence of D152 Resin Prewashing Process on the Quality of Spectinomycin
Spectinomycin is an alkaline water-soluble aminoglycoside antibiotic,produced by the fer-mentation of actinospectacin.The prewashing process of D152 resin with EDTA-2Na was studied,by selecting the proper concentration,pH and flow rate of the prewashing solution,the extraction of high purity macromycin hydrochloride was realized,and the recovery process of EDTA-2Na was deter-mined.The optimal prewashing parameters were obtained:the concentration of EDTA-2Na solution is 0.015 mol/L,the pH of prewashing solution is 7.5～8.0,and the flow rate is 1.0～2.0 BV/h.The prewashing process is simple,low cost and high recovery,which ensures the adsorption yield of D152 resin and realizes the green extraction.
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