Analysis on the Effect of Selegiline Combined with Levodopa in the Treatment of Patients with Parkinson's Disease
Objective To analyze the effect of selegiline combined with levodopa in the treatment of patients with Parkinson's disease.Methods 108 patients with Parkinson's disease admitted to our hospital from January 2019 to January 2023 were randomly divided into routine group and observation group,with 54 cases in each group.The routine group was treated with oral levodopa,and the observation group was treated with selegiline on the basis of the routine group.The clinical efficacy,UPDRS scores and neurotrophic factor levels were compared between the two groups.Results The total effective rate of treatment in the observation group was 98.15%,higher than 81.48%in the routine group(P<0.05).After treatment,the UPDRS-Ⅰ,UPDRS-Ⅱand UPDRS-Ⅲscores of the observation group were lower than those of the routine group(P<0.05).After treatment,the NGF,BDNF and Aβ1-42 levels of the observation group were higher than those of the routine group(P<0.05).Conclusions Selegiline combined with levodopa has significant effect in the treatment of patients with Parkinson's disease,which can significantly reduce the UPDRS scores and improve the neurotrophic factor levels.
国家科技期刊平台
NSTL
万方数据
维普
