血清VEGF、TAP、CA125及HE4检测在卵巢上皮性癌诊断中的临床价值
Clinical Value of Serum VEGF,TAP,CA125 and HE4 Detection in the Diagnosis of Epithelial Ovarian Cancer
王亚茹 1张冬丽 1王宁1
作者信息
- 1. 河南大学淮河医院妇产科,河南开封 475000
- 折叠
摘要
目的 探讨血清VEGF、TAP、CA125 及HE4 检测诊断卵巢上皮性癌(EOC)的价值.方法 191 例卵巢肿瘤手术患者根据病理结果分为观察组(EOC)和对照组(卵巢良性肿瘤),比较两组的VEGF、TAP、CA125 及HE4 水平.比较观察组早期和晚期患者的各指标水平,分析各指标诊断EOC的效能.结果 观察组的VEGF、TAP、CA125 及HE4 水平均高于对照组(P<0.001).观察组晚期患者的VEGF、CA125、HE4 水平均高于早期患者(P<0.05).四项指标联合检测诊断EOC的AUC和效能均优于单独检测(P<0.05).结论 EOC患者的VEGF、TAP、CA125 和HE4 呈异常高表达,联合检测可提高诊断准确性.
Abstract
Objective To explore the value of serum VEGF,TAP,CA125 and HE4 detection in the diagnosis of epithelial ovarian cancer(EOC).Methods 191 patients with ovarian tumor surgery were divided into the observation group(EOC)and the control group(benign ovarian tumor)according to the pathological results.The levels of VEGF,TAP,CA125 and HE4 were compared between the two groups.The levels of each index in the early and advanced patients in the observation group were compared,and the efficiencies of each index in the diagnosis of EOC were analyzed.Results The levels of VEGF,TAP,CA125 and HE4 in the observation group were higher than those in the control group(P<0.001).In the observation group,the levels of VEGF,CA125 and HE4 in the advanced patients were higher than those in the early patients(P<0.05).The AUC and efficacy of combined detection of the four indicators in the diagnosis of EOC were better than those of single detection(P<0.05).Conclusions The expressions of VEGF,TAP,CA125 and HE4 in EOC patients are abnormally high,and combined detection can improve the diagnostic accuracy.
关键词
VEGF/TAP/CA125/HE4/上皮性卵巢癌/诊断Key words
VEGF/TAP/CA125/HE4/Epithelial ovarian cancer/Diagnosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据