甲基强的松龙联合维生素D治疗对亚急性甲状腺炎患者甲状腺功能及炎性反应的影响
Impact of Methylprednisolone Combined with Vitamin D on Thyroid Function and Inflammatory Response of Patients with Subacute Thyroiditis
逯海波 1马瑜瑾 1李利平 1刘艺丹 1赵瑞 1邓琼琼 1李慧垚 1姜宏卫1
作者信息
- 1. 河南科技大学临床医学院/河南科技大学第一附属医院内分泌代谢中心/河南省罕见病重点实验室,河南洛阳 471003
- 折叠
摘要
目的 探讨甲基强的松龙联合维生素D治疗亚急性甲状腺炎的临床效果.方法 80 例亚急性甲状腺炎患者随机分为两组各 40 例.对照组采用甲基强的松龙治疗,研究组采用甲基强的松龙联合维生素D治疗.比较两组的甲状腺功能[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]、炎性指标[红细胞沉降率(ESR)、C反应蛋白(CRP)]以及不良反应.结果 治疗后,研究组的FT3 及FT4 水平均低于对照组,TSH水平高于对照组(P＜0.05).治疗后,研究组的ESR及CRP水平均低于对照组(P＜0.05).治疗期间,两组患者均未出现明显不良反应.结论 甲基强的松龙联合维生素D治疗亚急性甲状腺炎患者可显著改善其甲状腺功能,减轻炎性反应,安全性高.
Abstract
Objective To explore the clinical effect of methylprednisolone combined with vitamin D in the treatment of subacute thyroiditis.Methods 80 patients with subacute thyroiditis were randomly divided into two groups,with 40 cases in each group.The control group was treated with methylprednisolone,and the study group was treated with methylprednisolone combined with vitamin D.The thyroid function[free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)],inflammatory indicators[erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)]and adverse reactions were compared between the two groups.Results After treatment,the levels of FT3 and FT4 in the study group were lower than those in the control group,and the TSH level was higher than that in the control group(P<0.05).After treatment,the levels of ESR and CRP in the study group were lower than those in the control group(P<0.05).During the treatment,no obvious adverse reaction occurred in the two groups.Conclusions Methylprednisolone combined with vitamin D in the treatment of patients with subacute thyroiditis can obviously improve their thyroid function,reduce inflammatory response,and has high safety.
关键词
亚急性甲状腺炎/甲基强的松龙/维生素D/甲状腺功能/炎性反应Key words
Subacute thyroiditis/Methylprednisolone/Vitamin D/Thyroid function/Inflammatory response引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据