环磷酰胺联合醋酸泼尼松治疗结缔组织病相关性间质性肺疾病的临床研究
Clinical Study of Cyclophosphamide Combined with Prednisone Acetate in the Treatment of Connective Tissue Disease-Re-lated Interstitial Lung Disease
张阳 1秦晨曼 2郑庆凯1
作者信息
- 1. 焦作市人民医院呼吸与危重症科,河南焦作 454000
- 2. 焦作市人民医院风湿免疫科,河南焦作 454000
- 折叠
摘要
目的 分析环磷酰胺联合醋酸泼尼松治疗结缔组织病相关性间质性肺疾病(CTD-ILD)的临床效果.方法 88 例CTD-ILD患者随机分为两组各 44 例.对照组采用复方环磷酰胺片治疗,研究组在对照组基础上采用醋酸泼尼松片治疗.比较两组的临床疗效、炎性因子以及不良反应.结果 研究组的治疗总有效率为 90.91%,显著高于对照组的 75.00%(P＜0.05).治疗后,研究组的血清CRP、PCT、IL-6 水平均显著低于对照组(P＜0.05).两组的不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 环磷酰胺联合醋酸泼尼松治疗CTD-ILD的效果显著,可减轻患者炎性反应,安全性高.
Abstract
Objective To analyze the clinical effect of cyclophosphamide combined with prednisone acetate in the treatment of connective tissue disease-related interstitial lung disease(CTD-ILD).Methods 88 patients with CTD-ILD were randomly divided into two groups,with 44 cases in each group.The control group was treated with compound cyclophosphamide tablets,and the study group was treated with prednisone acetate tablets on the basis of the control group.The clinical efficacy,inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 90.91%,significantly higher than 75.00%in the control group(P<0.05).After treatment,the levels of serum CRP,PCT and IL-6 in the study group were significantly lower than those in the control group(P<0.05).No significant difference was found in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Cyclophosphamide combined with prednisone acetate in the treatment of CTD-ILD has significant effect,which can relieve patients'inflammatory reaction and has high safety.
关键词
结缔组织病/间质性肺疾病/环磷酰胺/醋酸泼尼松/疗效/不良反应Key words
Connective tissue disease/Interstitial lung disease/Cyclophosphamide/Prednisone acetate/Efficacy/Adverse reaction引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据