Objective To analyze the effect and safety of chemotherapy combined with bevacizumab in the treatment of advanced non-small cell lung cancer(NSCLC).Methods 90 patients with advanced NSCLC were randomly divided into two groups.The control group was given conventional chemotherapy,and the observation group was treated with bevacizumab on the basis of the control group.The treatment effect and safety were compared between the two groups.Results After treatment,the total effective rate of treatment in the observation group was higher than that in the control group,and the levels of serum CEA,CA125 and VEGF were lower than those in the control group(P<0.05).No statistical difference was found in the incidences of adverse reactions between the two groups(P>0.05).Conclusions Chemotherapy combined with bevacizumab in the treatment of advanced NSCLC has significant effect and high safety.