CO2点阵激光治疗局限型白癜风的效果及对患者血清IL-2、ICAM-1及α-MSH水平的影响
Effect of CO2 Fractional Laser in the Treatment of Localized Vitiligo and the Impact on Serum IL-2,ICAM-1,and α-MSH Levels of Patients
李晓建 1邰海军 2郭金华 1刘倩 1史玉玲3
作者信息
- 1. 郑州四六○医院激光整形皮肤科,河南郑州 450007
- 2. 郑州四六○医院 院办,河南郑州 450007
- 3. 上海市皮肤病医院 院办,上海 200050
- 折叠
摘要
目的 分析CO2点阵激光治疗局限型白癜风的效果及对患者血清白介素-2(IL-2)、细胞间黏附分子-1(ICAM-1)及α黑色素细胞刺激素(α-MSH)水平的影响.方法 选取我院2020年4月至2023年1月收治的局限型白癜风患者84例,随机分为常规组(常规他克莫司软膏治疗)与激光组(他克莫司软膏+CO2点阵激光)各42例.比较两组的疗效、IL-2、ICAM-1、α-MSH水平和不良反应.结果 激光组治疗总有效率高于常规组(P＜0.05).治疗后,激光组血清IL-2、ICAM-1水平低于常规组,α-MSH水平高于常规组(P＜0.05).两组的不良反应发生率比较无统计学差异(P＞0.05).结论 CO2点阵激光治疗局限型白癜风患者可提高临床疗效,调节IL-2、ICAM-1及α-MSH水平,且不良反应少.
Abstract
Objective To analyze the effect of CO2 fractional laser in the treatment of localized vitiligo and the impact on serum levels of interleukin-2(IL-2),intercellular adhesion molecule-1(ICAM-1)and α-melanocyte stimulating hormone(α-MSH)of patients.Methods 84 patients with localized vitiligo admitted to our hospital from April 2020 to January 2023 were randomly divided into routine group(routine tacrolimus ointment)and laser group(tacrolimus ointment+CO2 fractional laser)equally.The efficacy,IL-2,ICAM-1,α-MSH levels and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the laser group was higher than that in the routine group(P＜0.05).After treatment,the serum IL-2 and ICAM-1 levels of the laser group were lower than those of the routine group,and the α-MSH level was higher than that of the routine group(P＜0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P＜0.05).Conclusions CO2 fractional laser in the treatment of patients with localized vitiligo can improve the clinical efficacy,and regulate the IL-2,ICAM-1 and α-MSH levels,with fewer adverse reactions.
关键词
白瘢风/CO2点阵激光/效果Key words
Vitiligo/CO2 factional laser/Effect引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据