Effect of CO2 Fractional Laser in the Treatment of Localized Vitiligo and the Impact on Serum IL-2,ICAM-1,and α-MSH Levels of Patients
Objective To analyze the effect of CO2 fractional laser in the treatment of localized vitiligo and the impact on serum levels of interleukin-2(IL-2),intercellular adhesion molecule-1(ICAM-1)and α-melanocyte stimulating hormone(α-MSH)of patients.Methods 84 patients with localized vitiligo admitted to our hospital from April 2020 to January 2023 were randomly divided into routine group(routine tacrolimus ointment)and laser group(tacrolimus ointment+CO2 fractional laser)equally.The efficacy,IL-2,ICAM-1,α-MSH levels and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the laser group was higher than that in the routine group(P＜0.05).After treatment,the serum IL-2 and ICAM-1 levels of the laser group were lower than those of the routine group,and the α-MSH level was higher than that of the routine group(P＜0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P＜0.05).Conclusions CO2 fractional laser in the treatment of patients with localized vitiligo can improve the clinical efficacy,and regulate the IL-2,ICAM-1 and α-MSH levels,with fewer adverse reactions.
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