Expression and Significance of Serum IL-2R,VEGF,and IL-8 in Patients with Myeloproliferative Tumors
Objective To analyze the expression and significance of serum interleukin-2R(IL-2R),interleukin-8(IL-8)and vascular endothelial growth factor(VEGF)in patients with myeloproliferative tumors.Methods 60 patients with myeloproliferative tumors(patient group)from October 2017 to October 2022 and 60 healthy individuals(control group)were selected,and the serum IL-2R,IL-8 and VEGF levels were detected.The serum IL-2R,IL-8 and VEGF levels before and after treatment were compared between the patient group and the control group.Results The serum IL-2R,IL-8 and VEGF levels of the patient group were higher than those of the control group(P＜0.05).The serum IL-2R and IL-8 levels of polycythemia vera(PV),essential thrombocytosis(ET),and primary myelofibrosis(PMF)patients increased sequentially(P＜0.05).Conclusions The serum IL-2R,IL-8,and VEGF levels are generally highly expressed in patients with myeloproliferative tumors,and significantly decrease after treatment.Serum IL-2R and IL-8 levels are significantly different among different types of patients,which can be used for diagnosis and differentiation.
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