骨髓增殖性肿瘤患者血清IL-2R、IL-8、VEGF表达情况及检测意义
Expression and Significance of Serum IL-2R,VEGF,and IL-8 in Patients with Myeloproliferative Tumors
马若巾 1张利娟2
作者信息
- 1. 郑州大学第五附属医院血液内科,河南郑州 450062
- 2. 解放军联勤保障部队第九八八医院血液肿瘤科,河南郑州 450007
- 折叠
摘要
目的 分析骨髓增殖性肿瘤患者血清白介素-2R(IL-2R)、白介素-8(IL-8)、血管内皮生长因子(VEGF)表达情况及检测意义.方法 选取2017年10月至2022年10月收治的骨髓增殖性肿瘤患者60例(患者组),另选取健康人60例(对照组),测量其血清IL-2R、IL-8、VEGF水平,对比患者组治疗前后及不同类型患者间血清IL-2R、IL-8、VEGF水平.结果 患者组血清IL-2R、IL-8、VEGF高于对照组(P＜0.05);真性红细胞增多症(PV)、原发性血小板增多症(ET)、原发性骨髓纤维化(PMF)患者的血清IL-2R、IL-8水平依次递增(P＜0.05).结论 骨髓增殖性肿瘤患者血清IL-2R、IL-8、VEGF水平普遍高表达,治疗后明显下降,不同类型患者的血清IL-2R、IL-8水平有显著差异,可用于诊断鉴别.
Abstract
Objective To analyze the expression and significance of serum interleukin-2R(IL-2R),interleukin-8(IL-8)and vascular endothelial growth factor(VEGF)in patients with myeloproliferative tumors.Methods 60 patients with myeloproliferative tumors(patient group)from October 2017 to October 2022 and 60 healthy individuals(control group)were selected,and the serum IL-2R,IL-8 and VEGF levels were detected.The serum IL-2R,IL-8 and VEGF levels before and after treatment were compared between the patient group and the control group.Results The serum IL-2R,IL-8 and VEGF levels of the patient group were higher than those of the control group(P＜0.05).The serum IL-2R and IL-8 levels of polycythemia vera(PV),essential thrombocytosis(ET),and primary myelofibrosis(PMF)patients increased sequentially(P＜0.05).Conclusions The serum IL-2R,IL-8,and VEGF levels are generally highly expressed in patients with myeloproliferative tumors,and significantly decrease after treatment.Serum IL-2R and IL-8 levels are significantly different among different types of patients,which can be used for diagnosis and differentiation.
关键词
骨髓增殖性肿瘤/白介素-2R/白介素-8/血管内皮生长因子Key words
Myeloproliferative tumor/Interleukin-2R/Interleukin-8/Vascular endothelial growth factor引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据