术前炎性因子表达对腹股沟疝患者腹腔镜修补术后复发的影响及预测价值分析
Analysis on the Impact and Predictive Value of Preoperative Inflammatory Factor Expression on Recurrence after Laparo-scopic Repair in Patients with Inguinal Hernia
郑永慧 1禹学会 1张刘彦1
作者信息
- 1. 郑州煤炭工业(集团)有限责任公司总医院普外科,河南新密 452371
- 折叠
摘要
目的 分析术前炎性因子表达对腹股沟疝患者腹腔镜修补术后复发的影响及预测价值.方法 选择2019年5月至2022年7月在我院行腹腔镜疝修补术治疗的62例腹股沟疝患者,根据其术后3个月随访期间是否复发分为复发组(n=8)和未复发组(n=54).比较两组患者术前血清炎性因子水平,并分析相关指标对患者术后复发的影响及预测价值.结果 术前,两组血清TNF-α、IL-17水平比较无统计学差异(P＞0.05);复发组血清IL-6、hs-CRP水平高于未复发组(P＜0.05).经Logistic回归分析结果显示,术前血清IL-6、hs-CRP水平是腹股沟疝患者腹腔镜修补术后复发的影响因素(OR＞1,P＜0.05);ROC曲线结果显示,术前血清IL-6联合hs-CRP预测术后复发的AUC为0.822,高于二者单独的0.730、0.792(P＜0.05).结论 术前血清IL-6、hs-CRP表达是腹股沟疝患者腹腔镜修补术后复发的影响因素,二者联合检测对其术后复发有一定预测价值.
Abstract
Objective To analyze the impact and predictive value of preoperative inflammatory factor expression on recurrence after laparoscopic repair in patients with inguinal hernia.Methods 62 patients with inguinal hernia undergoing laparoscopic hernia repair in our hospital from May 2019 to July 2022 were retrospectively analyzed and divided into recurrence group(n=8)and non-recurrence group(n=54)according to recurrence during the 3-month postoperative follow-up.The preoperative serum inflammatory factor levels were compared between the two groups,and the impact and predictive value of related indicators on postoperative recurrence were analyzed.Results Before operation,no statistical difference was found in the serum TNF-α and IL-17 levels between the two groups(P＞0.05);The serum IL-6 and hs-CRP levels of the recurrence group were higher than those of the non-recurrence group(P＜0.05).Logistic regression analysis showed that preoperative serum IL-6 and hs-CRP levels were the influencing factors of recurrence after laparoscopic repair in patients with inguinal hernia(OR＞1,P＜0.05).ROC curve results showed that the AUC of combined prediction of preoperative serum IL-6 and hs-CRP for postoperative recurrence was 0.822,higher than 0.730 and 0.792 alone(P＜0.05).Conclusions Preoperative serum IL-6 and hs-CRP expression are the influencing factors of recurrence after laparoscopic repair in patients with inguinal hernia,and the combined detection has certain predictive value for postoperative recurrence.
关键词
腹股沟疝/腹腔镜疝修补术/复发/炎性因子Key words
Inguinal hernia/Laparoscopic hernia repair/Recurrence/Inflammatory factor expression引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据