Clinical Study on Nimodipine Combined with Oxiracetam in the Treatment of Acute Cerebral Hemorrhage
Objective To explore the clinical efficacy of nimodipine combined with oxiracetam in the treatment of patients with acute cerebral hemorrhage and the impact on the oxidative stress response.Methods 86 patients with acute cerebral hemorrhage were randomly divided into observation group(n=43)and control group(n=43).The control group was treated with nimodipine,and the observation group was treated with nimodipine combined with oxiracetam.Both groups were treated for 15 days.The clinical efficacy,oxidative stress response and the incidence of adverse reactions were compared.Results The total effective rate of treatment in the observation group 95.35％,higher than 72.09％ in the control group(P＜0.05).After treatment,the serum superoxide dismutase(SOD)level of the observation group was higher than that of the control group,and the plasma malondialdehyde(MDA)level was lower than that of the control group(P＜0.05).During the treatment,no statistical difference was found in the incidence of adverse reactions(9.30％ vs.11.63％)between the two groups(P＞0.05).Conclusions Nimodipine combined with oxiracetam has significant treatment effect in the treatment of acute cerebral hemorrhage,can significantly reduce the patients'oxidative stress response,and is safe and reliable,which is worthy of clinical promotion and application.
国家科技期刊平台
NSTL
万方数据
