Objective To explore the clinical effect of etoposide combined with oxaliplatin in the treatment of non-small cell lung cancer(NSCLC).Methods 80 NSCLC patients admitted to our hospital from May 2019 to April 2021 were selected and divided into observation group and control group according to lottery method.The control group was treated with radiotherapy,and the observation group was treated with etoposide and oxaliplatin on the basis of the control group.The treatment effect,survival time and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 52.00%,higher than 25.00%in the control group(P<0.05).The median survival time of observation group was longer than that of control group(P<0.05).The incidences of myelosuppression and granulocytopenia in the observation group were 30.00%and 25.00%,respectively,higher than 10.00%and 7.50%in the control group(P<0.05).Conclusions Etoposide combined with oxaliplatin and radiotherapy has ideal effect in the treatment of NSCLC,which can prolong the survival time of patients,but the incidence of adverse reactions are relatively high.