首页|摩罗丹联合瑞巴派特及莫沙比利治疗慢性萎缩性胃炎的临床研究

摩罗丹联合瑞巴派特及莫沙比利治疗慢性萎缩性胃炎的临床研究

Clinical Study on Moluodan Combined with Rebamipide and Mosapride in Treatment of Chronic Atrophic Gastritis

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目的 探讨摩罗丹联合瑞巴派特及莫沙比利治疗慢性萎缩性胃炎患者的临床效果.方法 选取2020年2月至2022年3月我院收治的120例慢性萎缩性胃炎,随机分为观察组(n=60)和对照组(n=60).对照组采用瑞巴派特联合莫沙比利治疗,观察组在对照组基础上采用摩罗丹治疗,比较两组的治疗效果、血清胃蛋白酶原及炎性因子水平.结果 观察组治疗总有效率为96.67%,明显高于对照组的85.00%(P<0.05).治疗后,观察组胃蛋白酶原Ⅰ(PG Ⅰ)水平明显高于对照组,胃蛋白酶原Ⅱ(PG Ⅱ)、白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)水平明显低于对照组(P<0.05).结论 摩罗丹联合瑞巴派特及莫沙比利治疗慢性萎缩性胃炎的效果显著,可明显改善患者血清胃蛋白酶原及炎性因子水平,值得临床推广应用.
Objective To explore the clinical effect of Moluodan combined with rebamipide and mosapride in the treatment of patients with chronic atrophic gastritis.Methods 120 cases of patients with chronic atrophic gastritis admitted to our hospital from February 2020 to March 2022 were selected and randomly divided into observation group(n=60)and control group(n=60).The control group was treated with rebamipide combined with mosapride,and the observation group was treated with Moluodan on the basis of the control group.The treatment effect,serum pepsinogen and inflammatory factor levels were compared between the two groups.Results The total effective rate of the treatment in the observation group was 96.67%,significantly higher than 85.00%in the control group(P<0.05).After treatment,the pepsinogen Ⅰ(PG Ⅰ)of the observation group was significantly higher than that of the control group,and the pepsinogen Ⅱ(PG Ⅱ),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were significantly lower than those of the control group(P<0.05).Conclusions Moluodan combined with rebamipide and mosapride has significant effect in the treatment of chronic atrophic gastritis,which can significantly improve the levels of serum pepsinogen and inflammatory factors,and is worthy of clinical promotion and application.

MoluodanRebamipideMosaprideChronic atrophic gastritisTreatment effect

王莹莹、汪秀梅、陈晓燕

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郑州大学附属郑州中心医院消化内科,河南郑州 450001

摩罗丹 瑞巴派特 莫沙比利 慢性萎缩性胃炎 治疗效果

2024

临床医学工程
国家医疗保健器具工程技术研究中心

临床医学工程

影响因子:0.193
ISSN:1674-4659
年,卷(期):2024.31(3)
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