Clinical Effect of Bicyclol Combined with Reduced Glutathione in the Treatment of Patients with Drug-Induced Liver Injury Caused by Anti-Tuberculosis Drugs
Objective To explore the clinical effect of bicyclol combined with reduced glutathione in the treatment of patients with drug-induced liver injury(DILI)caused by anti-tuberculosis drugs.Methods 100 patients with DILI caused by anti-tuberculosis drugs admitted to our hospital from January 2021 to December 2022 were selected and randomly divided into control group(50 cases)and study group(50 cases).The control group was treated with reduced glutathione,and the study group was treated with bicyclol combined with reduced glutathione.Both groups were treated continuously for 3 weeks.The clinical efficacy,liver function indicators(AST,ALT,TBIL,GGT)and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 96.00％,higher than 80.00％in the control group(P＜0.05).After treatment,the AST,ALT,TBIL and GGT levels of the study group were lower than those of the control group(P＜0.05).During treatment,no statistical difference was found in the incidence of adverse reactions(10.00％ vs.6.00％)between the two groups(P＞0.05).Conclusions Bicyclol combined with reduced glutathione in the treatment of patients with DILI caused by anti-tuberculosis drugs can significantly improve the clinical efficacy and liver function of patients,and is safe and reliable,which is worthy of clinical promotion and application.
Drug-induced liver injuryBicyclolReduced glutathioneClinical efficacyLiver function
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