首页|乙酰半胱氨酸联合布地奈德治疗慢性阻塞性肺疾病的临床研究

乙酰半胱氨酸联合布地奈德治疗慢性阻塞性肺疾病的临床研究

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目的 探讨乙酰半胱氨酸联合布地奈德治疗慢性阻塞性肺疾病(COPD)的临床效果.方法 100例COPD患者随机分为两组各50例.在常规治疗基础上,对照组给予布地奈德治疗,研究组给予乙酰半胱氨酸联合布地奈德治疗.比较两组的临床疗效、肺功能指标以及不良反应.结果 研究组的治疗总有效率为94.00%,显著高于对照组的78.00%(P<0.05).治疗后,研究组的FEV,、FEV1/FVC、FEV,%均显著高于对照组(P<0.05).两组的不良反应总发生率比较,差异无统计学意义(P>0.05).结论 乙酰半胱氨酸联合布地奈德治疗COPD的效果显著,安全性高,可明显改善患者的肺功能.
Clinical Study on Acetylcysteine Combined with Budesonide in the Treatment of Chronic Obstructive Pulmonary Disease
Objective To explore the clinical effect of acetylcysteine combined with budesonide in the treatment of chronic obstructive pulmonary disease(COPD).Methods 100 COPD patients were randomly divided into two groups,with 50 cases in each group.On the basis of conventional treatment,the control group was treated with budesonide,while the study group was treated with acetylcysteine combined with budesonide.The clinical efficacy,lung function indicators,and adverse reactions were compared between two groups.Results The total effective rate of treatment in the study group was 94.00%,significantly higher than the 78.00%in the control group(P<0.05).After treatment,the FEV1,FEV1/FVC,and FEV1%in the study group were significantly higher than those in the control group(P<0.05).No significant difference was found in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Acetylcysteine combined with budesonide in the treatment of COPD has significant effect and high safety,and can obviously improve the lung function of patients.

AcetylcysteineBudesonideChronic obstructive pulmonary diseaseLung function

张红霞、庞方方

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通许第一医院呼吸消化内科,河南开封 475400

乙酰半胱氨酸 布地奈德 慢性阻塞性肺疾病 肺功能

2024

临床医学工程
国家医疗保健器具工程技术研究中心

临床医学工程

影响因子:0.193
ISSN:1674-4659
年,卷(期):2024.31(4)
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