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宫颈癌患者血清lncRNA CCAT2、miR-944的表达及其临床意义

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目的 分析宫颈癌患者血清lncRNA CCAT2、miR-944的表达及其临床意义.方法 选取120例宫颈癌患者为宫颈癌组,120例宫颈上皮瘤样病变患者为病变组,120例健康者为对照组,比较三组的血清lncRNA CCAT2、miR-944表达水平,分析二者联合检测对宫颈癌的诊断效能.结果 血清lncRNA CCAT2、miR-944的表达水平由高到低依次为宫颈癌组、病变组、对照组(均P<0.05).入院时血清lncRNA CCAT2、miR-944联合检测诊断宫颈癌的AUC为0.916,高于各指标单独检测.结论 宫颈癌患者的血清lncRNA CCAT2、miR-944水平呈异常高表达,二者联合检测对宫颈癌的诊断价值较高.
Expressions of Serum lncRNA CCAT2 and miR-944 in Patients with Cervical Cancer and Their Clinical Significance
Objective To analyze the expressions of serum lncRNA CCAT2 and miR-944 in patients with cervical cancer and their clinical significance.Methods 120 patients with cervical cancer were selected as the cervical cancer group,120 patients with cervical intraepithelial neoplasia were selected as the lesion group,and 120 healthy people were selected as the control group.The expression levels of serum lncRNA CCAT2 and miR-944 in the three groups were compared,and the diagnostic effiicacy of the combined detection of the two for cervical cancer was analyzed.Results The expression levels of serum lncRNA CCAT2 and miR-944 from high to low were cervical cancer group,lesion group and control group(all P<0.05).The A UC of combined detection of serum lncRNA CCAT2 and miR-944 at admission in the diagnosis of cervical cancer was 0.916,higher than that of each index alone.Conclusions The levels of serum lncRNA CCAT2 and miR-944 in patients with cervical cancer are abnormally high,and the combined detection of the two has high diagnostic value for cervical cancer.

Cervical cancerlncRNA CCAT2miR-944Diagnostic efficacy

李冰熠、黄好亮

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郑州大学附属洛阳中心医院妇科,河南洛阳 471000

宫颈癌 lncRNA CCAT2 miR-944 诊断效能

2024

临床医学工程
国家医疗保健器具工程技术研究中心

临床医学工程

影响因子:0.193
ISSN:1674-4659
年,卷(期):2024.31(4)
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