Analysis on the Effect of Ulinastatin Combined with Meropenem in the Treatment of Severe Pneumonia
Objective To analyze the clinical effect of ulinastatin combined with meropenem in the treatment of patients with severe pneumonia.Methods 80 patients with severe pneumonia were randomly divided into two groups.On the basis of conventional treatment,the control group was treated with meropenem,while the combined treatment group was treated with ulinastatin combined with meropenem.The efficacy,inflammatory factors,lung function,and adverse reactions were compared between the two groups.Results The total effective rate of the combined treatment group was significantly higher than that of the control group(P＜0.05).After treatment,the levels of serum IL-1β,TNF-α of the combined treatment group were significantly lower than those of the control group,and FEV1 and FVC were significantly higher than those of the control group(P＜0.05).No statistically significant difference was found in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusions Ulinastatin combined with meropenem in the treatment of severe pneumonia can down-regulate the levels of inflammatory factors and improve lung function of patients without obvious adverse reactions.
Severe pneumoniaUlinastatinMeropenemInflammatory factorLung function
万方数据
维普
