Objective To analyze the clinical effect of ulinastatin combined with meropenem in the treatment of patients with severe pneumonia.Methods 80 patients with severe pneumonia were randomly divided into two groups.On the basis of conventional treatment,the control group was treated with meropenem,while the combined treatment group was treated with ulinastatin combined with meropenem.The efficacy,inflammatory factors,lung function,and adverse reactions were compared between the two groups.Results The total effective rate of the combined treatment group was significantly higher than that of the control group(P＜0.05).After treatment,the levels of serum IL-1β,TNF-α of the combined treatment group were significantly lower than those of the control group,and FEV1 and FVC were significantly higher than those of the control group(P＜0.05).No statistically significant difference was found in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusions Ulinastatin combined with meropenem in the treatment of severe pneumonia can down-regulate the levels of inflammatory factors and improve lung function of patients without obvious adverse reactions.
关键词
重症肺炎/乌司他丁/美罗培南/炎性因子/肺功能
Key words
Severe pneumonia/Ulinastatin/Meropenem/Inflammatory factor/Lung function
维普
万方数据