Objective To explore the effect of Xingnaojing combined with modified decompressive craniectomy in the treatment of patients with severe traumatic brain injury.Methods 105 patients with severe traumatic brain injury were divided into two groups according to different treatment methods.The reference group was treated with modified decompressive craniectomy,while the combined group was treated with Xingnaojing injection on the basis of the reference group.The levels of inflammatory factors,brain metabolic indicators,adverse reactions,and prognosis were compared between two groups.Results 2 weeks after surgery,the levels of serum TNF-a and IL-2 of the combined group were lower than those of the reference group,the level of PCT was higher than that of the reference group,and the CCP,CEO2 and SVO2 were higher than those of the reference group(P＜0.05).No statistically significant difference was found in the total incidence of adverse reactions between the two groups(P＞0.05).The proportion of good prognosis of the combined group was higher than that of the reference group(P＜0.05).Conclusions Xingnaojing combined with modified decompressive craniectomy in the treatment of patients with severe traumatic brain injury can alleviate their inflammatory reactions,and improve brain metabolism and prognosis.
关键词
重型颅脑损伤/改良去骨瓣减压术/醒脑静/炎性因子/脑代谢
Key words
Severe traumatic brain injury/Modified decompressive craniectomy/Xingnaojing/Inflammatory factor/Brain metabolism
维普
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