Impact of Recombinant Human Growth Hormone Combined with Calcium Gluconate Oral Solution Treatment on Growth and Development and Bone Metabolism of Children with Dwarfism
Objective To explore the effect of recombinant human growth hormone combined with calcium gluconate oral solution in the treatment of children with dwarfism.Methods 100 children with dwarfism were randomly divided into two groups.The reference group was treated with recombinant human growth hormone,while the combined group was treated with calcium gluconate oral solution on the basis of the reference group.The indicators of growth and development and bone metabolism,and the adverse reactions of the two groups were compared.Results After 6 months of treatment,the height,weight and bone age of the combined group were significantly higher than those of the reference group,the levels of BALP and OC were significantly higher than those of the reference group,and the β-CTX level was significantly lower than that of the reference group(P＜0.05).No significant difference was found in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusions Recombinant human growth hormone combined with calcium gluconate oral solution in the treatment of dwarfism can significantly promote the growth and development of children,and improve their bone metabolism levels.
Calcium gluconate oral solutionDwarfismGrowth and developmentBone metabolism
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