Objective To explore the effect and safety of evolocumab combined with atorvastatin calcium in the treatment of CHD complicated with hyperlipidemia.Methods 102 patients with CHD complicated with hyperlipidemia were randomly divided into the control group(atorvastatin calcium)and the observation group(evolocumab+atorvastatin calcium).The efficacy and adverse reactions were compared between the two groups.Results After treatment,the levels of TG,TC,LDL-C,and ApoB in the observation group were lower than those in the control group,and the LDL-C compliance rate was higher than that in the control group(P＜0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions Evolocumab combined with atorvastatin calcium in the treatment of CHD complicated with hyperlipidemia can lower patients'blood lipid levels,and the safety is still acceptable.
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