Impact of Lipid Metabolism on the Therapeutic Effect of Immunosuppressive Agents Combined with Glucocorticoids in Pa-tients with Idiopathic Membranous Nephropathy
Impact of Lipid Metabolism on the Therapeutic Effect of Immunosuppressive Agents Combined with Glucocorticoids in Pa-tients with Idiopathic Membranous Nephropathy
Objective To explore the impact of lipid metabolism on the therapeutic effect of immunosuppressive agents combined with glucocorticoids in patients with idiopathic membranous nephropathy.Methods A total of 86 patients with idiopathic membranous nephropathy treated with immunosuppressive agents combined with glucocorticoids were divided into non-improved group and improved group according to the therapeutic effect.The baseline data and lipid metabolism indicators of the two groups were compared,and the related influencing factors of therapeutic effect were analyzed.Results After 6 months of treatment,16 of 86 patients with idiopathic membranous nephropathy did not improve,accounted for 18.60％.The levels of TC and TG in the non-improved group were higher than those in the improved group(P＜0.05).Logistic regression analysis showed that TC and TG levels were the influencing factors of the therapeutic effect of immunosuppressive agents combined with glucocorticoids in patients with idiopathic membranous nephropathy(OR＞1,P＜0.05).Conclusions Lipid metabolism level of patients with idiopathic membranous nephropathy will affect the therapeutic effect of immunosuppressive agents combined with glucocorticoids.
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