Effect of Quetiapine Combined with Buspirone in the Treatment of Schizophrenia
Objective To analyze the effect of quetiapine combined with buspirone in the treatment of patients with schizophrenia(SCH).Methods 100 SCH patients admitted to our hospital from April 2020 to March 2023 were selected and divided into observation group and control group according to odd even order.The control group was treated with quetiapine,while the observation group was treated with quetiapine combined with buspirone.The symptom score,serum indicator levels and quality of life were compared between the two groups.Results After treatment,the PANSS score of the observation group was lower than that of the control group(P＜0.05).After treatment,the glial-derived neurotrophic factor(GDNF),brain derived neurotrophic factor(BDNF)and 5-hydroxytryptamine(5-HT)levels of the observation group were higher than those of the control group(P＜0.05).After treatment,the GQOLI-74 score of the observation group was higher than that of the control group(P＜0.05).Conclusions Quetiapine combined with buspirone can relieve the clinical symptoms,regulate the neurotransmitter levels,and improve the quality of life of SCH patients.
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