Impact of Budesonide Nebulization Inhalation Combined with Piperacillin Tazobactam on Lung Function and Inflammatory Response in Patients with Chronic Obstructive Pulmonary Disease
Objective To analyze the effect of budesonide nebulization inhalation combined with piperacillin tazobactam on lung function and inflammatory response in patients with chronic obstructive pulmonary disease(COPD).Methods 100 COPD patients admitted to our hospital from March 2021 to March 2022 were selected and randomly divided into two groups,with 50 cases in each group.The control group was treated with piperacillin tazobactam,and the observation group was treated with budesonide nebulization inhalation on this basis for 14 days.The clinical efficacy,lung function indicators(FEV1,FVC,PEF),inflammatory factors(PCT,CRP,TNF-α)were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.00％,higher than 78.00％in the control group(P＜0.05).After treatment,the FEV1,FVC and PEF of the observation group were higher than those of the control group(P＜0.05).After treatment,the PCT,CRP,and TNF-α levels of the observation group were lower than those of the control group(P＜0.05).Conclusions Budesonide nebulization inhalation combined with piperacillin tazobactam in the treatment of COPD patients can significantly improve the clinical efficacy and lung function,and reduce the inflammatory reactions,which is worthy of clinical promotion.
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