不同剂量艾司奥美拉唑四联疗法对老年HP感染相关胃炎患者胃肠激素、炎症指标水平的影响
Impact of Different Doses of Esomeprazole Quadruple Therapy on Gastrointestinal Hormones and Inflammatory Indicator Levels of Elderly Patients with HP Infection-Related Gastritis
袁亮亮 1刘星宇 1赵琪1
作者信息
- 1. 共青城市人民医院内二科,江西九江 332020
- 折叠
摘要
目的 探讨不同剂量艾司奥美拉唑四联疗法治疗老年幽门螺旋杆菌(HP)感染相关胃炎患者的效果.方法 72例行四联疗法的老年HP感染相关胃炎患者随机分为对照组和观察组,分别给予标准剂量和高剂量艾司奥美拉唑,比较两组的胃肠激素、炎症指标及不良反应.结果 治疗后,观察组的G-17、PGⅠ、GH水平均高于对照组,CRP、IL-6、TNF-α水平均低于对照组(P＜0.05).结论 高剂量艾司奥美拉唑四联疗法治疗老年HP感染相关胃炎患者可明显改善其胃肠激素水平,减轻炎性反应.
Abstract
Objective To explore the effect of different doses of esomeprazole quadruple therapy in the treatment of elderly patients with helicobacter pylori(HP)infection-related gastritis.Methods 72 elderly patients with HP infection-related gastritis who underwent quadruple therapy were randomly divided into the control group and the observation group,which were given standard dose and high dose of esomeprazole respectively.The gastrointestinal hormones,inflammatory indicators and adverse reactions of the two groups were compared.Results After treatment,the levels of G-17,PG Ⅰ and GH in the observation group were higher than those in the control group,and the levels of CRP,IL-6,TNF-α were lower than those in the control group(P＜0.05).Conclusions High-dose esomeprazole quadruple therapy in the treatment of elderly patients with HP infection-related gastritis can significantly improve their gastrointestinal hormone levels and reduce inflammatory reaction.
关键词
幽门螺旋杆菌/胃炎/艾司奥美拉唑/四联疗法Key words
Helicobacter pylori/Gastritis/Esomeprazole/Quadruple therapy引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据