Impact of Tacrolimus Combined with Prednisone on Renal Function and Lipid Metabolism in Patients with Idiopathic Membranous Nephropathy
Objective To explore the impact of tacrolimus combined with prednisone on renal function and lipid metabolism in patients with idiopathic membranous nephropathy(IMN).Methods 110 IMN patients admitted to our hospital were selected and divided into control group(n=54)and study group(n=56)according to different treatment methods.In addition to routine treatment,the control group was treated with prednisone,and the study group was treated with tacrolimus on the basis of the control group.The 24-hour urine protein quantification(24hUpro),glomerular filtration rate(eGFR),total cholesterol(TC),low-density lipoprotein(LDL-C),triglyceride(TG),and high-density lipoprotein(HDL-C)levels and adverse reactions were compared between the two groups.Results After 6 months of treatment,the 24hUPro,TC,LDL-C and TG levels of the study group were lower than those of the control group,and the eGFR and HDL-C levels were higher than those of the control group(P<0.05).During the treatment,the incidence of adverse reactions in the study group was 16.07%,which had no statistical difference with 14.81%in the control group(P>0.05).Conclusions Tacrolimus combined with prednisone in the treatment of IMN patients can significantly improve the renal function and lipid metabolism,which is safe,reliable,and worthy of clinical promotion and application.
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