The Changes of Serum IL-17 and IL-23 Levels and Immune Function Indicators in Patients with HBV Infection and Their Clinical Significance
Objective To analyze the changes of serum IL-17 and IL-23 levels and immune function indicators in patients with hepatitis B virus(HBV)infection.Methods 110 patients with HBV infection admitted to our hospital from October 2020 to November 2022 were selected and divided into HBV carrier group,chronic hepatitis B group and cirrhosis group according to the disease progression.The levels of serum IL-17,IL-23 and immune function indicators were compared among the three groups,and the correlations between the above indicators and the severity of the disease were analyzed.Results The levels of serum IL-17,IL-23,IgG,IgA and IgM in the three groups from high to low were cirrhosis group,chronic hepatitis B group and HBV carrier group(P<0.05).Spearman correlation analysis showed that serum IL-17,IL-23,IgG,IgA and IgM levels were significantly positively correlated with the severity of the disease in patients with HBV infection(P<0.05).Conclusions The levels of serum IL-17,IL-23,IgG,IgA and IgM are positively correlated with the disease severity of HBV infection.
Hepatitis B virusIL-17IL-23Immune functionDisease progressionCorrelation
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