Impact of XELOX Regimen Combined with Hyperthermic Intraperitoneal Chemotherapy on the Prognosis of Patients with Colorectal Cancer Surgery
Objective To explore the impact of XELOX regimen combined with hyperthermic intraperitoneal chemotherapy(HIPEC)on the prognosis of patients with colorectal cancer(CRC)surgery.Methods A total of 72 patients with CRC were randomly divided into two groups.After radical resection,the control group was given XELOX chemotherapy,and the observation group was given XELOX chemotherapy combined with HIPEC.The clinical efficacy,survival situation and adverse reactions were compared between the two groups.Results After chemotherapy,the total effective rate and 6-month disease-free survival rate of the observation group were higher than those of the control group(P<0.05).The incidence of bone marrow suppression of the observation group was higher than that of the control group,and the incidence of gastrointestinal reactions was lower than that of the control group(P<0.05);No significant difference was found in the incidence of liver and kidney function injury between the two groups(P>0.05).Conclusions XELOX regimen combined with HIPEC can improve the clinical efficacy and short-term prognosis of CRC patients,but may increase the adverse reactions of patients.
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