高频重复经颅磁刺激联合药物治疗对帕金森病患者自主神经功能、认知功能及睡眠质量的影响
Impact of High-Frequency Repetitive Transcranial Magnetic Stimulation Combined with Drug Therapy on Autonomic Nervous Function,Cognitive Function and Sleep Quality in Patients with Parkinson's Disease
雷萌 1刘会星 1耿纪超1
作者信息
- 1. 河南省直第三人民医院神经内科,河南郑州 450018
- 折叠
摘要
目的 探讨高频重复经颅磁刺激(rTMS)联合药物治疗对帕金森病(PD)患者自主神经功能、认知功能及睡眠质量的影响.方法 将2019年1月至2021年11月我院收治的96例PD患者随机分为研究组(n=48)和参照组(n=48).参照组采用常规药物治疗,研究组在参照组基础上采用高频rTMS治疗,比较两组的自主神经功能、认知功能及睡眠质量.结果 治疗1个月后,两组帕金森病自主神经症状量表(SCOPA-AUT)、匹兹堡睡眠质量指数量表(PSQI)评分低于治疗前,简易精神状态检查量表(MMSE)评分高于治疗前(P＜0.05);研究组SCOPA-AUT、PSQI评分低于参照组,MMSE评分高于参照组(P＜0.05).结论 高频rTMS联合药物治疗可明显改善PD患者的自主神经功能、认知功能,提升其睡眠质量,值得临床推广.
Abstract
Objective To explore the impact of high-frequency repetitive transcranial magnetic stimulation(rTMS)combined with drug therapy on autonomic nervous function,cognitive function and sleep quality in patients with Parkinson's disease(PD).Methods 96 PD patients admitted to our hospital from January 2019 to November 2021 were randomly divided into study group(n=48)and reference group(n=48).The reference group was treated with conventional drugs,and the study group was treated with high-frequency rTMS on the basis of the reference group.The autonomic nervous function,cognitive function and sleep quality were compared between the two groups.Results After 1 month of treatment,the SCOPA-AUT scores and PSQI scores of the two groups were lower than those before treatment,and the MMSE scores were higher than those before treatment(P＜0.05);The SCOPA-AUT score and PSQI score of the study group were lower than those of the reference group,and the MMSE score was higher than that of the reference group(P＜0.05).Conclusions High-frequency rTMS combined with drug therapy can significantly improve the autonomic nervous function and cognitive function of PD patients,and enhance the sleep quality,which is worthy of clinical promotion.
关键词
帕金森病/高频重复经颅磁刺激/药物治疗/自主神经功能/认知功能/睡眠质量Key words
Parkinson's disease/High-frequency repetitive transcranial magnetic stimulation/Drug therapy/Autonomic nervous function/Cognitive function/Sleep quality引用本文复制引用
基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20230672)
出版年
2024
国家科技期刊平台
NSTL
万方数据