三七皂苷对人脐静脉内皮细胞增殖的影响
Impact of Panax Notoginseng Saponins on Proliferation of Human Umbilical Vein Endothelial Cells
俞方毅 1宁波 1叶劲超 1梁一鸣 1陈家祥 1许智蕾1
作者信息
- 1. 广州市红十字会医院神经外科,广东广州 510220
- 折叠
摘要
目的 探讨活血类中药成分三七总皂苷(PNS)对于人脐静脉内皮细胞(HUVECs)增殖的影响.方法 体外培养HUVECs,分为空白对照组、PNS低浓度组(10mg/L)、PNS高浓度组(50mg/L),各组给予相应浓度药物干预,采用MTT法检测HUVECs增殖率.结果 PNS低浓度组、PNS高浓度组的HUVECs增殖率均高于空白对照组(P＜0.05).结论 PNS可促进HUVECs增殖,促进血管管腔的形成,对内皮细胞具有积极的影响,在维持血管健康和功能方面发挥着至关重要的作用.
Abstract
Objective To explore the impact of panax notoginseng saponins(PNS)on proliferation of human umbilical vein endothelial cells(HUVECs).Methods HUVECs were cultured in vitro and divided into blank control group,PNS low concentration group(10 mg/L)and PNS high concentration group(50 mg/L).Each group was given corresponding concentration of drug intervention,and the proliferation rate of HUVECs was detected by MTT assay.Results The proliferation rates of HUVECs in the PNS low concentration group and PNS high concentration group were higher than those of the blank control group(P＜0.05).Conclusions PNS can promote the proliferation of HUVECs,and promote the formation of vascular lumen,which exerts positive effect on endothelial cells and plays a vital role in maintaining blood vessel health and function.
关键词
三七总皂苷/缺血性卒中/人脐静脉内皮细胞/增殖Key words
Panax notoginseng saponins/Ischemic stroke/Human umbilical vein endothelial cell/Proliferation引用本文复制引用
基金项目
广东省中医药科研项目面上项目(20221305)
出版年
2024
国家科技期刊平台
NSTL
万方数据