Analysis on Correlation between Serum FGF23,Uric Acid Levels and Atrial Fibrosis in Patients with Persistent Atrial Fibrillation
Objective To analyze the correlation between serum fibroblast growth factor 23(FGF23),uric acid(UA)levels and atrial fibrosis in patients with persistent atrial fibrillation.Methods 166 patients with atrial fibrillation admitted to our hospital from July 2020 to August 2022 were selected and divided into persistent atrial fibrillation group(n=86)and paroxysmal atrial fibrillation group(n=80)according to the disease severity.Another 50 patients with sinus rhythm diagnosed in our hospital during the same period were selected as the control group.The serum FGF23,UA and atrial fibrosis biochemical markers(PICP,PⅢNP,LN,HA)were compared among the three groups,and the correlation between serum FGF23,UA and atrial fibrosis biochemical markers in patients with persistent atrial fibrillation was analyzed.Results The serum FGF23,UA,PICP,PⅢNP,LN and HA levels of the persistent atrial fibrillation group were higher than those of the paroxysmal atrial fibrillation group and the control group,and the serum FGF23 and PICP levels of the paroxysmal atrial fibrillation group were higher than those of the control group(P＜0.05).Serum FGF23 in patients with persistent atrial fibrillation showed significant positive correlation with PICP,PⅢNP,LN,and HA(P＜0.05);Serum UA showed significant positive correlation with PICP and PⅢNP(P＜0.05)and no significant correlation with LN and HA(P＞0.05).Conclusions Serum FGF23 and UA levels in patients with persistent atrial fibrillation are abnormally elevated,and have a certain correlation with atrial fibrosis.
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